Study Set Content:
shunt involves the conversion of ribulose-5-phosphate to ribose-5-phosphate (R-5-P) through a series of independent reactions.
non-oxidative phase
The non-oxidative phase of the HMP shunt involves the conversion of
ribulose-5-phosphate to ribose-5-phosphate (R-5-P)
The non-oxidative phase of the HMP shunt involves the conversion of ribulose-5-phosphate to ribose-5-phosphate (R-5-P) through a series of
independent reactions
R-5-P in this reaction can be returned to the glycolytic pathway as
fructose-6-phosphate
This step requires the (blank) enzyme
transketolase
• R-5-P in this reaction can be returned to the glycolytic pathway as fructose-6-phosphate. This step requires the transketolase enzyme with the presence of the
thiamine cofactor
The importance of the HMP shunt is (blank) that generated in the reaction.
R-5-P and NADPH molecules
undergoes a series of reactions to create the different ribose sugars that comprise the DNA and RNA molecules, required to carry genetic information.
• R-5-P
R-5-P also converts into
erythrose-4- phosphate
Moreover, R-5-P also converts into erythrose-4- phosphate for the synthesis of
aromatic amino acids
this pathway is an essential source of these
ribose sugars
• NADPH takes part in anabolism processes such as that of
synthesis steroids and fatty acids.
NADPH is also required to reduce the molecule
glutathione
Using (blank) oxidized glutathione
glutathione reductase and NAPDH
e. Using glutathione reductase and NAPDH, (blank) glutathione
oxidized
NADPH is also required to reduce the molecule glutathione. Using glutathione reductase and NAPDH, oxidized glutathione is converted into it
reduced form
NADPH is also required to reduce the molecule glutathione. Using glutathione reductase and NAPDH, oxidized glutathione is converted into its reduced form, and can detoxify
free radicals and peroxides;
his limits the possibility of any free radical injury in tissues with NADPH present, namely that the
red blood cells
Oxidative phase
glucose enzyme
hexokinase
glucose to
Glucose-6- phosphate
