Study Set Content:
widely used cardiac glycosides
Cardiac drug digoxin
is group of drug used in the therapy of hypercholesterolemia that has receive the greatest success and financial reward for the pharmaceutical industry during the last two decades
Cardiac drug digoxin
Separated a new glycoside from digitalis purpurea - known as digoxin
Sydney smith
discovered that the foxglove plant, Digitalis purpurea, was beneficial to those suffering from abnormal fluid buildup.
➢ William Withering
isolated the active components consisted mainly of digitoxin.
➢ E. Humolle and T. Quevenne
Isolated the other glycosides of digitalis
Claude Nativelled and Oswald Schmiedberg
The correct structure of digoxin was actually established more than (blank) years later
50
established the correct structure of digitoxin
Adolf Windaus
known as statins (Akiro Endo), are one of the cornerstones in the prevention of both primary and secondary heart diseases. (e.g. atorvastatin, simvastatin)
Cholesterol-lowering drugs
statins
Pravastatin
Atorvastatin
Compactin or Lovastatin
The search was a success, and Endo’s next assignment was to find a drug which would block the enzyme (blank) a key enzyme essential to the production of cholesterol
hydroxymethylglutaryl-coenzyme A (HMG-CoA)
With Endo’s interest and background, he searched for fungi that would block this enzyme. In 1973, Endo found a substance made by the mold Penicillium citrinum that was a potent inhibitor on the enzyme needed to make cholesterol; it was named
compactin
With Endo’s interest and background, he searched for fungi that would block this enzyme. In 1973, Endo found a substance made by the mold Penicillium citrinum that was a potent inhibitor on the enzyme needed to make cholesterol; it was named compactin (mevastatin) With the collaboration of (blank), a physician treating patients with extremely high cholesterol due to a genetic defect
Akira Yamamoto
With Endo’s interest and background, he searched for fungi that would block this enzyme. In 1973, Endo found a substance made by the mold Penicillium citrinum that was a potent inhibitor on the enzyme needed to make cholesterol; it was named compactin (mevastatin) With the collaboration of Akira Yamamoto, a physician treating patients with extremely high cholesterol due to a genetic defect, Endo prepared samples of his drug, and it was administered to an 18- year-old (blank)% effective
27
Merck discovered a substance that was nearly identical to Endo’s; this one was named(blank)
lovastatin (Mevacor)
Sankyo eventually gave up compactin and pursued another statin that they licensed to BristolMyers Squibb Co., which was sold as
Pravachol
won the Nobel Prize in Physiology or Medicine for their work in cholesterol metabolism
Michael S. Brown and Joseph Goldstein
