Study Set Content:
61- Flashcard

It is also valuable in reducing involuntary voiding in

patients with neurologic disease, eg. children with

meningomyelocele.

Oxybutynin

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62- Flashcard

(blank) oxybutynin or instillation of the drug by

(blank) into the bladder in such patients appears to

improve bladder capacity and continence and to

reduce infection and renal damage.

Oral, catheter

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63- Flashcard

reduces the need for

multiple daily doses. of oxybutynin

Transdermally applied, oral

extended-release formulation

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64- Flashcard

a nonselective antagonist, has been

approved and is comparable in efficacy and side

effects to oxybutynin.

Trospium,

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65- Flashcard

are recently approved

antagonists that have greater selectivity for M 3

receptors than oxybutynin or trospium.

Darifenacin and solifenacin

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66- Flashcard

have the advantage of

once-daily dosing because of their long half-lives.

Darifenacin and solifenacin

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67- Flashcard

M 3-selective

antimuscarinics, are available for use in adults with

urinary incontinence. They have many of the

qualities of darifenacin and solifenacin and are

available in extended-release tablets.

Tolterodine and fesoterodine,

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68- Flashcard

a newer antimuscarinic agent,

• An alternative treatment for urinary incontinence

Propiverine,

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69- Flashcard

An alternative treatment for urinary incontinence

refractory to antimuscarinic drugs is intrabladder

injection of

botulinum toxin A.

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70- Flashcard

a tricyclic antidepressant drug with

strong antimuscarinic actions

Imipramine,

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71- Flashcard

is used for the treatment of overdoses of

cholinesterase inhibitor insecticides & some types

of mushroom poisoning.

Atropine

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72- Flashcard

The potential use of cholinesterase inhibitors as

chemical warfare(blank) also requires an

awareness of the methods for treating acute

poisoning.

"nerve gases"

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73- Flashcard

Both the nicotinic and the muscarinic effects of the

cholinesterase inhibitors can be

life-threatening.

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74- Flashcard

To reverse the muscarinic effects, a (blank) (not

quaternary) drug must be used (preferably

atropine) to treat CNS effects as well as the

peripheral effects of the organophosphate

inhibitors.

tertiary amine

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75- Flashcard

Large doses of atropine may be needed to oppose

the muscarinic effects of extremely potent agents

like

parathion

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76- Flashcard

In this life-threatening situation, as much as (blank) may be required for as long as

➢ 1 month for full control of muscarinic excess

1 g of

atropine per day

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77- Flashcard

A second class of compounds, composed of

substituted (blank) capable of regenerating active

enzyme from the organophosphorus-

cholinesterase complex, is also available to treat

organophosphorus poisoning.

oximes

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78- Flashcard

These oxime agents include

pralidoxime (PAM),

diacetylmonoxime (DAM), Obidoxime, and

others.

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79- Flashcard

is administered by intravenous

infusion, 1-2 z prven over 15-30 minutes.

Pralidoxime

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80- Flashcard

Administration of multiple doses of pralidoxime

over several days may be useful in

severe poisoning.

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